BioAssay: a long road through the years toward Open Science

Toward open behavioral science.

Toward Open Behavioral Science Karen E. Adolph a , Rick O. Gilmore b , Clinton Freeman c , Penelope Sanderson c & David Millman d a Department of Psychology, New York University, New York, New York b Department of Psychology, The Pennsylvania State University, University Park, Pennsylvania c Department of Psychology, The University of Queensland, St Lucia, Queensland, Australia d Division of Li...

The Long Road to Eradicate Rinderpest

The Long and Winding Road: Forty Years of Argumentation

In this paper I review my engagement with argumentation over the past forty years. I describe the perspective I brought from philosophy and the Civil Service, and consider a number of aspects of computational argumentation: knowledge based systems, explanation, context, audiences, schemes and models. A key feature of argumentation is that it is an activity which has to be actively engaged with,...

PubChem BioAssay: A Decade’s Development toward Open High-Throughput Screening Data Sharing

High-throughput screening (HTS) is now routinely conducted for drug discovery by both pharmaceutical companies and screening centers at academic institutions and universities. Rapid advance in assay development, robot automation, and computer technology has led to the generation of terabytes of data in screening laboratories. Despite the technology development toward HTS productivity, fewer eff...

Bioassay bashing is bad science.

The Spheres of Influence, “Assessing Assays” (Schmidt 2002), in the May 2002 issue of EHP criticizes the National Toxicology Program rodent bioassay (NTPRB) without discussing its importance in regulation and public health. The Spheres article (Schmidt 2002) does not express concern for the validity of alternative transgenic methods proposed to replace the NTPRB for detecting carcinogens. By fo...